Facilitation of glutamate, but not GABA, release in Familial Alzheimer's APP mutant Knock‐in rats with increased β‐cleavage of APP

Amyloid precursor protein (APP) modulates glutamate release via cytoplasmic and intravesicular interactions with the synaptic vesicle release machinery. The intravesicular domain, called ISVAID, contains the BACE1 cleavage site of APP. We have tested the functional significance of BACE1 processing o...

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Detalles Bibliográficos
Autores principales: Tambini, Marc D., Yao, Wen, D'Adamio, Luciano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826143/
https://www.ncbi.nlm.nih.gov/pubmed/31496118
http://dx.doi.org/10.1111/acel.13033

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826143/
https://www.ncbi.nlm.nih.gov/pubmed/31496118
http://dx.doi.org/10.1111/acel.13033

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