The Catalytic Mechanisms of the Reactions between Tryptophan Indole-Lyase and Nonstandard Substrates: The Role of the Ionic State of the Catalytic Group Accepting the Cα Proton of the Substrate

In the reaction between tryptophan indole-lyase (TIL) and a substrate containing a bad leaving group (L-serine), general acid catalysis is required for the group's elimination. During this stage, the proton originally bound to the C(α) atom of the substrate is transferred to the leaving group,...

Descripción completa

Detalles Bibliográficos
Autores principales: Faleev, N. G., Tsvetikova, M. A., Gogoleva, O. I., Kulikova, V. V., Revtovich, S. V., Kochetkov, K. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: A.I. Gordeyev 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826157/
https://www.ncbi.nlm.nih.gov/pubmed/31720020
http://dx.doi.org/10.32607/20758251-2019-11-3-82-88

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826157/
https://www.ncbi.nlm.nih.gov/pubmed/31720020
http://dx.doi.org/10.32607/20758251-2019-11-3-82-88

Ejemplares similares