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The Catalytic Mechanisms of the Reactions between Tryptophan Indole-Lyase and Nonstandard Substrates: The Role of the Ionic State of the Catalytic Group Accepting the Cα Proton of the Substrate

In the reaction between tryptophan indole-lyase (TIL) and a substrate containing a bad leaving group (L-serine), general acid catalysis is required for the group's elimination. During this stage, the proton originally bound to the C(α) atom of the substrate is transferred to the leaving group,...

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Detalles Bibliográficos
Autores principales:	Faleev, N. G., Tsvetikova, M. A., Gogoleva, O. I., Kulikova, V. V., Revtovich, S. V., Kochetkov, K. A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	A.I. Gordeyev 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826157/ https://www.ncbi.nlm.nih.gov/pubmed/31720020 http://dx.doi.org/10.32607/20758251-2019-11-3-82-88

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