An oligomeric state‐dependent switch in the ER enzyme FICD regulates AMPylation and deAMPylation of BiP

AMPylation is an inactivating modification that alters the activity of the major endoplasmic reticulum (ER) chaperone BiP to match the burden of unfolded proteins. A single ER‐localised Fic protein, FICD (HYPE), catalyses both AMPylation and deAMPylation of BiP. However, the basis for the switch in...

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Detalles Bibliográficos
Autores principales: Perera, Luke A, Rato, Claudia, Yan, Yahui, Neidhardt, Lisa, McLaughlin, Stephen H, Read, Randy J, Preissler, Steffen, Ron, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826200/
https://www.ncbi.nlm.nih.gov/pubmed/31531998
http://dx.doi.org/10.15252/embj.2019102177

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826200/
https://www.ncbi.nlm.nih.gov/pubmed/31531998
http://dx.doi.org/10.15252/embj.2019102177

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