Endurance exercise resistance to lipotoxic cardiomyopathy is associated with cardiac NAD(+)/dSIR2/PGC-1α pathway activation in old Drosophila

Lipotoxic cardiomyopathy is caused by excessive lipid accumulation in myocardial cells and it is a form of cardiac dysfunction. Cardiac PGC-1α overexpression prevents lipotoxic cardiomyopathy induced by a high-fat diet (HFD). The level of NAD(+) and Sir2 expression upregulate the transcriptional act...

Descripción completa

Detalles Bibliográficos
Autores principales: Wen, Deng-Tai, Zheng, Lan, Li, Jin-xiu, Cheng, Dan, Liu, Yang, Lu, Kai, Hou, Wen-qi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826281/
https://www.ncbi.nlm.nih.gov/pubmed/31624074
http://dx.doi.org/10.1242/bio.044719

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826281/
https://www.ncbi.nlm.nih.gov/pubmed/31624074
http://dx.doi.org/10.1242/bio.044719

Ejemplares similares