Restriction of mitochondrial calcium overload by mcu inactivation renders a neuroprotective effect in zebrafish models of Parkinson's disease

The loss of dopaminergic neurons (DA) is a pathological hallmark of sporadic and familial forms of Parkinson's disease (PD). We have previously shown that inhibiting mitochondrial calcium uniporter (mcu) using morpholinos can rescue DA neurons in the PTEN-induced putative kinase 1 (pink1)(−/−)...

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Detalles Bibliográficos
Autores principales: Soman, Smijin K., Bazała, Michal, Keatinge, Marcus, Bandmann, Oliver, Kuznicki, Jacek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826286/
https://www.ncbi.nlm.nih.gov/pubmed/31548178
http://dx.doi.org/10.1242/bio.044347

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826286/
https://www.ncbi.nlm.nih.gov/pubmed/31548178
http://dx.doi.org/10.1242/bio.044347

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