Identification of Celastrol as a Novel YAP-TEAD Inhibitor for Cancer Therapy by High Throughput Screening with Ultrasensitive YAP/TAZ–TEAD Biosensors

The Hippo pathway has emerged as a key signaling pathway that regulates a broad range of biological functions, and dysregulation of the Hippo pathway is a feature of a variety of cancers. Given this, some have suggested that disrupting the interaction of the Hippo core component YAP and its paralog...

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Detalles Bibliográficos
Autores principales: Nouri, Kazem, Azad, Taha, Ling, Min, van Rensburg, Helena J. Janse, Pipchuk, Alexander, Shen, He, Hao, Yawei, Zhang, Jianmin, Yang, Xiaolong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826516/
https://www.ncbi.nlm.nih.gov/pubmed/31635084
http://dx.doi.org/10.3390/cancers11101596

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826516/
https://www.ncbi.nlm.nih.gov/pubmed/31635084
http://dx.doi.org/10.3390/cancers11101596

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