p53-Mediated Oxidative Stress Enhances Indirubin-3′-Monoxime-Induced Apoptosis in HCT116 Colon Cancer Cells by Upregulating Death Receptor 5 and TNF-Related Apoptosis-Inducing Ligand Expression

Indirubin-3′-monoxime (I3M) exhibits anti-proliferative activity in various cancer cells; however, its anti-cancer mechanism remains incompletely elucidated. This study revealed that I3M promotes the expression of death receptor 5 (DR5) and tumor necrosis factor (TNF)-related apoptosis-inducing liga...

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Detalles Bibliográficos
Autores principales: Dilshara, Matharage Gayani, Molagoda, Ilandarage Menu Neelaka, Jayasooriya, Rajapaksha Gedara Prasad Tharanga, Choi, Yung Hyun, Park, Cheol, Lee, Kyoung Tae, Lee, Seungheon, Kim, Gi-Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826553/
https://www.ncbi.nlm.nih.gov/pubmed/31546731
http://dx.doi.org/10.3390/antiox8100423

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826553/
https://www.ncbi.nlm.nih.gov/pubmed/31546731
http://dx.doi.org/10.3390/antiox8100423

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