Targeting G-quadruplexes with Organic Dyes: Chelerythrine–DNA Binding Elucidated by Combining Molecular Modeling and Optical Spectroscopy

The DNA-binding of the natural benzophenanthridine alkaloid chelerythrine (CHE) has been assessed by combining molecular modeling and optical absorption spectroscopy. Specifically, both double-helical (B-DNA) and G-quadruplex sequences—representative of different topologies and possessing biological...

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Detalles Bibliográficos
Autores principales: Terenzi, Alessio, Gattuso, Hugo, Spinello, Angelo, Keppler, Bernhard K., Chipot, Christophe, Dehez, François, Barone, Giampaolo, Monari, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826623/
https://www.ncbi.nlm.nih.gov/pubmed/31658666
http://dx.doi.org/10.3390/antiox8100472

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826623/
https://www.ncbi.nlm.nih.gov/pubmed/31658666
http://dx.doi.org/10.3390/antiox8100472

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