Synergistic Anti-Tumor Effect of mTOR Inhibitors with Irinotecan on Colon Cancer Cells

Advanced colorectal cancer has a poor prognosis because of metastasis formation and resistance to combined therapies. Downstream of PI3K/Akt and Ras/MAPK pathways, the mTOR kinase plays a decisive role in treatment failure. We previously established that irinotecan has antiangiogenic properties and...

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Detalles Bibliográficos
Autores principales: Reita, Damien, Bour, Cyril, Benbrika, Radhia, Groh, Audrey, Pencreach, Erwan, Guérin, Eric, Guenot, Dominique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826690/
https://www.ncbi.nlm.nih.gov/pubmed/31627299
http://dx.doi.org/10.3390/cancers11101581

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826690/
https://www.ncbi.nlm.nih.gov/pubmed/31627299
http://dx.doi.org/10.3390/cancers11101581

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