Cargando…

The PAK1-Stat3 Signaling Pathway Activates IL-6 Gene Transcription and Human Breast Cancer Stem Cell Formation

Cancer stem cells (CSCs) have unique properties, including self-renewal, differentiation, and chemoresistance. In this study, we found that p21-activated kinase (PAK1) inhibitor (Group I, PAK inhibitor, IPA-3) and inactivator (ivermectin) treatments inhibit cell proliferation and that tumor growth o...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kim, Ji-Hyang, Choi, Hack Sun, Kim, Su-Lim, Lee, Dong-Sun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826853/ https://www.ncbi.nlm.nih.gov/pubmed/31658701 http://dx.doi.org/10.3390/cancers11101527

Ejemplares similares

Disruption of the NF-κB/IL-8 Signaling Axis by Sulconazole Inhibits Human Breast Cancer Stem Cell Formation
por: Choi, Hack Sun, et al.
Publicado: (2019)

Dihydrotanshinone-Induced NOX5 Activation Inhibits Breast Cancer Stem Cell through the ROS/Stat3 Signaling Pathway
por: Kim, Su-Lim, et al.
Publicado: (2019)

Inhibitory Effects of Tangeretin, a Citrus Peel-Derived Flavonoid, on Breast Cancer Stem Cell Formation through Suppression of Stat3 Signaling
por: Ko, Yu-Chan, et al.
Publicado: (2020)

Plant Volatile, Phenylacetaldehyde Targets Breast Cancer Stem Cell by Induction of ROS and Regulation of Stat3 Signal
por: Choi, Hack Sun, et al.
Publicado: (2020)

The Antiasthma Medication Ciclesonide Suppresses Breast Cancer Stem Cells through Inhibition of the Glucocorticoid Receptor Signaling-Dependent YAP Pathway
por: Kim, Su-Lim, et al.
Publicado: (2020)

Betavulgarin Isolated from Sugar Beet (Beta vulgaris) Suppresses Breast Cancer Stem Cells through Stat3 Signaling
por: Liu, Ren, et al.
Publicado: (2020)

6-Methoxymellein Isolated from Carrot (Daucus carota L.) Targets Breast Cancer Stem Cells by Regulating NF-κB Signaling
por: Liu, Ren, et al.
Publicado: (2020)

Triterpene Acid (3-O-p-Coumaroyltormentic Acid) Isolated From Aronia Extracts Inhibits Breast Cancer Stem Cell Formation through Downregulation of c-Myc Protein
por: Choi, Hack Sun, et al.
Publicado: (2018)

Caudatin Isolated from Cynanchum auriculatum Inhibits Breast Cancer Stem Cell Formation via a GR/YAP Signaling
por: Zhen, Xing, et al.
Publicado: (2020)

Primaquine Inhibits the Endosomal Trafficking and Nuclear Localization of EGFR and Induces the Apoptosis of Breast Cancer Cells by Nuclear EGFR/Stat3-Mediated c-Myc Downregulation
por: Kim, Ji-Hyang, et al.
Publicado: (2021)

The FDA-Approved Anti-Asthma Medicine Ciclesonide Inhibits Lung Cancer Stem Cells through Hedgehog Signaling-Mediated SOX2 Regulation
por: Choi, Hack Sun, et al.
Publicado: (2020)

Functional Deficits in Pak5, Pak6 and Pak5/Pak6 Knockout Mice
por: Furnari, Melody A., et al.
Publicado: (2013)

13R,20-Dihydroxydocosahexaenoic Acid, a Novel Dihydroxy- DHA Derivative, Inhibits Breast Cancer Stemness through Regulation of the Stat3/IL-6 Signaling Pathway by Inducing ROS Production
por: Wang, Lifang, et al.
Publicado: (2021)

Machilin D, a Lignin Derived from Saururus chinensis, Suppresses Breast Cancer Stem Cells and Inhibits NF-κB Signaling
por: Zhen, Xing, et al.
Publicado: (2020)

Coriolic Acid (13-(S)-Hydroxy-9Z, 11E-octadecadienoic Acid) from Glasswort (Salicornia herbacea L.) Suppresses Breast Cancer Stem Cell through the Regulation of c-Myc
por: Ko, Yu-Chan, et al.
Publicado: (2020)

Alterations in IL-6/STAT3 Signaling by Korean Mistletoe Lectin Regulate the Self-Renewal Activity of Placenta-Derived Mesenchymal Stem Cells
por: Kim, Gi Dae, et al.
Publicado: (2019)

Differential roles and regulation of the protein kinases PAK4, PAK5 and PAK6 in melanoma cells
por: Murugesan, Gavuthami, et al.
Publicado: (2022)

Genetic Association between Inflammatory-Related Polymorphism in STAT3, IL-1β, IL-6, TNF-α and Idiopathic Recurrent Implantation Failure
por: Kwon, Min Jung, et al.
Publicado: (2023)

Direct Interaction between AR and PAK6 in Androgen-Stimulated PAK6 Activation
por: Liu, Xia, et al.
Publicado: (2013)

BRD4/nuclear PD-L1/RelB circuit is involved in the stemness of breast cancer cells
por: Kim, Su-Lim, et al.
Publicado: (2023)

IL-32γ suppresses lung cancer stem cell growth via inhibition of ITGAV-mediated STAT5 pathway
por: Lee, Yong Sun, et al.
Publicado: (2019)

Novel Small Molecule Inhibitors Targeting the IL-6/STAT3 Pathway or IL-1β
por: Yoo, Jihye, et al.
Publicado: (2022)

Butein Inhibits Cell Growth by Blocking the IL-6/IL-6Rα Interaction in Human Ovarian Cancer and by Regulation of the IL-6/STAT3/FoxO3a Pathway
por: Park, Sun-Ae, et al.
Publicado: (2023)

Crystal Structures of the p21-Activated Kinases PAK4, PAK5, and PAK6 Reveal Catalytic Domain Plasticity of Active Group II PAKs
por: Eswaran, Jeyanthy, et al.
Publicado: (2007)

Pak1 Regulates the Orientation of Apical Polarization and Lumen Formation by Distinct Pathways
por: deLeon, Orlando, et al.
Publicado: (2012)

Ribonucleic acid interference knockdown of IL-6 enhances the efficacy of cisplatin in laryngeal cancer stem cells by down-regulating the IL-6/STAT3/HIF1 pathway
por: Fu, Qiang, et al.
Publicado: (2017)

IL‐37 inhibits invasion and metastasis in non‐small cell lung cancer by suppressing the IL‐6/STAT3 signaling pathway
por: Jiang, Mingfang, et al.
Publicado: (2018)

Research progress of cancer stem cells and IL-6/STAT3 signaling pathway in esophageal adenocarcinoma
por: Chen, Mei, et al.
Publicado: (2020)

Epigenetic Alterations of IL-6/STAT3 Signaling by Placental Stem Cells Promote Hepatic Regeneration in a Rat Model with CCl4-induced Liver Injury
por: Jung, Jieun, et al.
Publicado: (2015)

Type I IFN induced IL1-Ra expression in hepatocytes is mediated by activating STAT6 through the formation of STAT2: STAT6 heterodimer
por: Wan, Lei, et al.
Publicado: (2008)

Progress in Understanding the IL-6/STAT3 Pathway in Colorectal Cancer
por: Lin, Yan, et al.
Publicado: (2020)

The m6A writers regulated by the IL-6/STAT3 inflammatory pathway facilitate cancer cell stemness in cholangiocarcinoma
por: Ye, Hua, et al.
Publicado: (2022)

Lipocalin 2 potentially contributes to tumorigenesis from colitis via IL-6/STAT3/NF-κB signaling pathway
por: Kim, Se Lim, et al.
Publicado: (2022)

CircRNA_100782 regulates pancreatic carcinoma proliferation through the IL6-STAT3 pathway
por: Chen, Genwen, et al.
Publicado: (2017)

PAK4 signaling in health and disease: defining the PAK4–CREB axis
por: Won, So-Yoon, et al.
Publicado: (2019)

PAK4–6 in cancer and neuronal development
por: Minden, Audrey
Publicado: (2012)

The SRF-YAP-IL6 axis promotes breast cancer stemness
por: Kim, Tackhoon, et al.
Publicado: (2016)

Mitochondrial PAK6 inhibits prostate cancer cell apoptosis via the PAK6-SIRT4-ANT2 complex
por: Li, Tingting, et al.
Publicado: (2020)

TLR2 ligation induces the production of IL-23/IL-17 via IL-6, STAT3 and NF-kB pathway in patients with primary Sjogren's syndrome
por: Kwok, Seung-Ki, et al.
Publicado: (2012)

Active Components with Inhibitory Activities on IFN-γ/STAT1 and IL-6/STAT3 Signaling Pathways from Caulis Trachelospermi
por: Liu, Xiao-Ting, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_s9fabdo83bgk75abcdg83t5j9k