Multiple sclerosis disease progression: Contributions from a hypoxia–inflammation cycle

Hypoxia has been associated with multiple sclerosis (MS) and is an important area of research. Hypoxia can exacerbate inflammation via the prolylhydroxylase pathway. Inflammation can also trigger hypoxia by damaging mitochondria and endothelial cells to impair blood flow regulation. We hypothesize t...

Descripción completa

Detalles Bibliográficos
Autores principales: Yang, Runze, Dunn, Jeff F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2018
Materias:
Personal Viewpoint
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826859/
https://www.ncbi.nlm.nih.gov/pubmed/30052113
http://dx.doi.org/10.1177/1352458518791683
_version_ 1783465191034322944
author Yang, Runze
Dunn, Jeff F
author_facet Yang, Runze
Dunn, Jeff F
author_sort Yang, Runze
collection PubMed
description Hypoxia has been associated with multiple sclerosis (MS) and is an important area of research. Hypoxia can exacerbate inflammation via the prolylhydroxylase pathway. Inflammation can also trigger hypoxia by damaging mitochondria and endothelial cells to impair blood flow regulation. We hypothesize that there is a “hypoxia–inflammation cycle” in MS which plays an important role in MS disease progression. Therapies that break this cycle may be an interesting area of exploration for treatment of MS.
format Online
Article
Text
id pubmed-6826859
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher SAGE Publications
record_format MEDLINE/PubMed
spelling pubmed-68268592019-12-04 Multiple sclerosis disease progression: Contributions from a hypoxia–inflammation cycle Yang, Runze Dunn, Jeff F Mult Scler Personal Viewpoint Hypoxia has been associated with multiple sclerosis (MS) and is an important area of research. Hypoxia can exacerbate inflammation via the prolylhydroxylase pathway. Inflammation can also trigger hypoxia by damaging mitochondria and endothelial cells to impair blood flow regulation. We hypothesize that there is a “hypoxia–inflammation cycle” in MS which plays an important role in MS disease progression. Therapies that break this cycle may be an interesting area of exploration for treatment of MS. SAGE Publications 2018-07-27 2019-11 /pmc/articles/PMC6826859/ /pubmed/30052113 http://dx.doi.org/10.1177/1352458518791683 Text en © The Author(s), 2018 http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Personal Viewpoint
Yang, Runze
Dunn, Jeff F
Multiple sclerosis disease progression: Contributions from a hypoxia–inflammation cycle
title Multiple sclerosis disease progression: Contributions from a hypoxia–inflammation cycle
title_full Multiple sclerosis disease progression: Contributions from a hypoxia–inflammation cycle
title_fullStr Multiple sclerosis disease progression: Contributions from a hypoxia–inflammation cycle
title_full_unstemmed Multiple sclerosis disease progression: Contributions from a hypoxia–inflammation cycle
title_short Multiple sclerosis disease progression: Contributions from a hypoxia–inflammation cycle
title_sort multiple sclerosis disease progression: contributions from a hypoxia–inflammation cycle
topic Personal Viewpoint
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826859/
https://www.ncbi.nlm.nih.gov/pubmed/30052113
http://dx.doi.org/10.1177/1352458518791683
work_keys_str_mv AT yangrunze multiplesclerosisdiseaseprogressioncontributionsfromahypoxiainflammationcycle
AT dunnjefff multiplesclerosisdiseaseprogressioncontributionsfromahypoxiainflammationcycle

Ejemplares similares