The Targeting of RNA Polymerase I Transcription Using CX-5461 in Combination with Radiation Enhances Tumour Cell Killing Effects in Human Solid Cancers

An increased rate of cellular proliferation is a hallmark of cancer and may be accompanied by an increase in ribosome biogenesis and dysregulation in rRNA synthesis. In this regard, CX-5461 has been developed as a novel RNA polymerase I inhibitor and is currently in Phase I/II clinical trials for so...

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Detalles Bibliográficos
Autores principales: Ismael, Mohammed, Webb, Roger, Ajaz, Mazhar, Kirkby, Karen J., Coley, Helen M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826960/
https://www.ncbi.nlm.nih.gov/pubmed/31557908
http://dx.doi.org/10.3390/cancers11101429

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826960/
https://www.ncbi.nlm.nih.gov/pubmed/31557908
http://dx.doi.org/10.3390/cancers11101429

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