The Structural Binding Mode of the Four Autotaxin Inhibitor Types that Differentially Affect Catalytic and Non-Catalytic Functions

Autotaxin (ATX) is a secreted lysophospholipase D, catalysing the conversion of lysophosphatidylcholine (LPC) to bioactive lysophosphatidic acid (LPA). LPA acts through two families of G protein-coupled receptors (GPCRs) controlling key cellular responses, and it is implicated in many physiological...

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Detalles Bibliográficos
Autores principales: Salgado-Polo, Fernando, Perrakis, Anastassis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826961/
https://www.ncbi.nlm.nih.gov/pubmed/31623219
http://dx.doi.org/10.3390/cancers11101577

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826961/
https://www.ncbi.nlm.nih.gov/pubmed/31623219
http://dx.doi.org/10.3390/cancers11101577

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