Ligand-Independent EGFR Activation by Anchorage-Stimulated Src Promotes Cancer Cell Proliferation and Cetuximab Resistance via ErbB3 Phosphorylation

Activation of the epidermal growth factor receptor (EGFR) pathway plays an important role in the progression of cancer and is associated with a poor prognosis in patients. The monoclonal antibody cetuximab, which displays EGFR extracellular domain-specific binding, has proven effective in the treatm...

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Detalles Bibliográficos
Autores principales: Nozaki, Masami, Yasui, Hiroki, Ohnishi, Yuichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826992/
https://www.ncbi.nlm.nih.gov/pubmed/31615015
http://dx.doi.org/10.3390/cancers11101552

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826992/
https://www.ncbi.nlm.nih.gov/pubmed/31615015
http://dx.doi.org/10.3390/cancers11101552

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