Unraveling the Heterogeneous Mutational Signature of Spontaneously Developing Tumors in MLH1(−/−) Mice

Mismatch repair deficient (MMR-D) tumors exemplify the prototypic hypermutator phenotype. Owing to the high mutation rates, plenty of neo-antigens are present on the tumor cells’ surface, ideally shared among different cancer types. The MLH1 knock out mouse represents a preclinical model that resemb...

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Detalles Bibliográficos
Autores principales: Gladbach, Yvonne Saara, Wiegele, Leonie, Hamed, Mohamed, Merkenschläger, Anna-Marie, Fuellen, Georg, Junghanss, Christian, Maletzki, Claudia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6827043/
https://www.ncbi.nlm.nih.gov/pubmed/31581674
http://dx.doi.org/10.3390/cancers11101485

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6827043/
https://www.ncbi.nlm.nih.gov/pubmed/31581674
http://dx.doi.org/10.3390/cancers11101485

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