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Unraveling the Heterogeneous Mutational Signature of Spontaneously Developing Tumors in MLH1(−/−) Mice
Mismatch repair deficient (MMR-D) tumors exemplify the prototypic hypermutator phenotype. Owing to the high mutation rates, plenty of neo-antigens are present on the tumor cells’ surface, ideally shared among different cancer types. The MLH1 knock out mouse represents a preclinical model that resemb...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6827043/ https://www.ncbi.nlm.nih.gov/pubmed/31581674 http://dx.doi.org/10.3390/cancers11101485 |