CRISPR-Cas9 Knockdown and Induced Expression of CD133 Reveal Essential Roles in Melanoma Invasion and Metastasis

CD133, known as prominin1, is a penta-span transmembrane glycoprotein presumably a cancer stem cell marker for carcinomas, glioblastomas, and melanomas. We showed that CD133(+) ‘melanoma-initiating cells’ are associated with chemoresistance, contributing to poor patient outcome. The current study in...

Descripción completa

Detalles Bibliográficos
Autores principales: Simbulan-Rosenthal, Cynthia M., Dougherty, Ryan, Vakili, Sahar, Ferraro, Alexandra M., Kuo, Li-Wei, Alobaidi, Ryyan, Aljehane, Leala, Gaur, Anirudh, Sykora, Peter, Glasgow, Eric, Agarwal, Seema, Rosenthal, Dean S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6827046/
https://www.ncbi.nlm.nih.gov/pubmed/31623313
http://dx.doi.org/10.3390/cancers11101490

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6827046/
https://www.ncbi.nlm.nih.gov/pubmed/31623313
http://dx.doi.org/10.3390/cancers11101490

Ejemplares similares