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CRISPR-Cas9 Knockdown and Induced Expression of CD133 Reveal Essential Roles in Melanoma Invasion and Metastasis

CD133, known as prominin1, is a penta-span transmembrane glycoprotein presumably a cancer stem cell marker for carcinomas, glioblastomas, and melanomas. We showed that CD133(+) ‘melanoma-initiating cells’ are associated with chemoresistance, contributing to poor patient outcome. The current study in...

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Detalles Bibliográficos
Autores principales:	Simbulan-Rosenthal, Cynthia M., Dougherty, Ryan, Vakili, Sahar, Ferraro, Alexandra M., Kuo, Li-Wei, Alobaidi, Ryyan, Aljehane, Leala, Gaur, Anirudh, Sykora, Peter, Glasgow, Eric, Agarwal, Seema, Rosenthal, Dean S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6827046/ https://www.ncbi.nlm.nih.gov/pubmed/31623313 http://dx.doi.org/10.3390/cancers11101490

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