Potent Activity of Composite Cyclin Dependent Kinase Inhibition against Hepatocellular Carcinoma

Alterations in cell cycle regulators are common in hepatocellular carcinoma (HCC). We tested the efficacy of composite inhibition of CDKs 1, 2, 5, and 9 through dinaciclib on HCC. In vitro, dinaciclib exhibited potent antiproliferative activities in HCC cell lines regardless of Rb or c-myc expressio...

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Detalles Bibliográficos
Autores principales: Shao, Yu-Yun, Li, Yong-Shi, Hsu, Hung-Wei, Lin, Hang, Wang, Han-Yu, Wo, Rita Robin, Cheng, Ann-Lii, Hsu, Chih-Hung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6827105/
https://www.ncbi.nlm.nih.gov/pubmed/31561409
http://dx.doi.org/10.3390/cancers11101433

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6827105/
https://www.ncbi.nlm.nih.gov/pubmed/31561409
http://dx.doi.org/10.3390/cancers11101433

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