Molecular basis for the function of the αβ heterodimer of human NAD-dependent isocitrate dehydrogenase

Mammalian mitochondrial NAD-dependent isocitrate dehydrogenase (NAD-IDH) catalyzes the decarboxylation of isocitrate into α-ketoglutarate in the tricarboxylic acid cycle. It exists as the α(2)βγ heterotetramer composed of the αβ and αγ heterodimers. Different from the αγ heterodimer that can be allo...

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Detalles Bibliográficos
Autores principales: Sun, Pengkai, Ma, Tengfei, Zhang, Tianlong, Zhu, Hanwen, Zhang, Jianyang, Liu, Yabing, Ding, Jianping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2019
Materias:
Protein Structure and Folding
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6827300/
https://www.ncbi.nlm.nih.gov/pubmed/31515270
http://dx.doi.org/10.1074/jbc.RA119.010099

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6827300/
https://www.ncbi.nlm.nih.gov/pubmed/31515270
http://dx.doi.org/10.1074/jbc.RA119.010099

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