Cargando…

Molecular basis for the function of the αβ heterodimer of human NAD-dependent isocitrate dehydrogenase

Mammalian mitochondrial NAD-dependent isocitrate dehydrogenase (NAD-IDH) catalyzes the decarboxylation of isocitrate into α-ketoglutarate in the tricarboxylic acid cycle. It exists as the α(2)βγ heterotetramer composed of the αβ and αγ heterodimers. Different from the αγ heterodimer that can be allo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sun, Pengkai, Ma, Tengfei, Zhang, Tianlong, Zhu, Hanwen, Zhang, Jianyang, Liu, Yabing, Ding, Jianping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2019
Materias:	Protein Structure and Folding
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6827300/ https://www.ncbi.nlm.nih.gov/pubmed/31515270 http://dx.doi.org/10.1074/jbc.RA119.010099

Ejemplares similares

Molecular mechanism of the dual regulatory roles of ATP on the αγ heterodimer of human NAD-dependent isocitrate dehydrogenase
por: Sun, Pengkai, et al.
Publicado: (2020)

Insights into the inhibitory mechanisms of NADH on the αγ heterodimer of human NAD-dependent isocitrate dehydrogenase
por: Liu, Yabing, et al.
Publicado: (2018)

Structure and allosteric regulation of human NAD-dependent isocitrate dehydrogenase
por: Sun, Pengkai, et al.
Publicado: (2020)

Structural Basis for Enzymatic Evolution from a Dedicated ADP-ribosyl Cyclase to a Multifunctional NAD Hydrolase
por: Liu, Qun, et al.
Publicado: (2009)

Molecular mechanism of the allosteric regulation of the αγ heterodimer of human NAD-dependent isocitrate dehydrogenase
por: Ma, Tengfei, et al.
Publicado: (2017)

The Geminin and Idas Coiled Coils Preferentially Form a Heterodimer That Inhibits Geminin Function in DNA Replication Licensing
por: Caillat, Christophe, et al.
Publicado: (2013)

A single mutation increases heavy-chain heterodimer assembly of bispecific antibodies by inducing structural disorder in one homodimer species
por: Stutz, Cian, et al.
Publicado: (2020)

A Novel Cofactor-binding Mode in Bacterial IMP Dehydrogenases Explains Inhibitor Selectivity
por: Makowska-Grzyska, Magdalena, et al.
Publicado: (2015)

Structural basis for the specificity of renin-mediated angiotensinogen cleavage
por: Carrell, Robin W., et al.
Publicado: (2019)

Structural Basis for the Regulation of Protein Kinase A by Activation Loop Phosphorylation
por: Steichen, Jon M., et al.
Publicado: (2012)

Structural basis for the glycosyltransferase activity of the Salmonella effector SseK3
por: Esposito, Diego, et al.
Publicado: (2018)

Structural Basis for Activity Regulation and Substrate Preference of Clostridial Collagenases G, H, and T
por: Eckhard, Ulrich, et al.
Publicado: (2013)

Structural Basis of Rnd1 Binding to Plexin Rho GTPase Binding Domains (RBDs)
por: Wang, Hui, et al.
Publicado: (2011)

Structural Basis for the Activity and Substrate Specificity of Fluoroacetyl-CoA Thioesterase FlK
por: Dias, Marcio V. B., et al.
Publicado: (2010)

Structural basis of cell-surface signaling by a conserved sigma regulator in Gram-negative bacteria
por: Jensen, Jaime L., et al.
Publicado: (2020)

Mutation of Gly-11 on the Dimer Interface Results in the Complete Crystallographic Dimer Dissociation of Severe Acute Respiratory Syndrome Coronavirus 3C-like Protease: CRYSTAL STRUCTURE WITH MOLECULAR DYNAMICS SIMULATIONS
por: Chen, Shuai, et al.
Publicado: (2008)

Structural Basis for Cul3 Protein Assembly with the BTB-Kelch Family of E3 Ubiquitin Ligases
por: Canning, Peter, et al.
Publicado: (2013)

Inter-domain Communication of Human Cystathionine β-Synthase: STRUCTURAL BASIS OF S-ADENOSYL-l-METHIONINE ACTIVATION
por: McCorvie, Thomas J., et al.
Publicado: (2014)

Structural basis of specific inhibition of extracellular activation of pro- or latent myostatin by the monoclonal antibody SRK-015
por: Dagbay, Kevin B., et al.
Publicado: (2020)

Structural Basis of Molecular Recognition of the Leishmania Small Hydrophilic Endoplasmic Reticulum-associated Protein (SHERP) at Membrane Surfaces
por: Moore, Benjamin, et al.
Publicado: (2011)

Molecular basis of cullin-3 (Cul3) ubiquitin ligase subversion by vaccinia virus protein A55
por: Gao, Chen, et al.
Publicado: (2019)

Structural Basis of Neutralization by a Human Anti-severe Acute Respiratory Syndrome Spike Protein Antibody, 80R
por: Hwang, William C., et al.
Publicado: (2006)

Structural Basis for Coronavirus-mediated Membrane Fusion: CRYSTAL STRUCTURE OF MOUSE HEPATITIS VIRUS SPIKE PROTEIN FUSION CORE
por: Xu, Yanhui, et al.
Publicado: (2004)

Structural Basis for the Allosteric Interference of Myosin Function by Reactive Thiol Region Mutations G680A and G680V
por: Preller, Matthias, et al.
Publicado: (2011)

Structural Basis for the Role of the K65R Mutation in HIV-1 Reverse Transcriptase Polymerization, Excision Antagonism, and Tenofovir Resistance
por: Das, Kalyan, et al.
Publicado: (2009)

Structural basis of inactivation of Ras and Rap1 small GTPases by Ras/Rap1-specific endopeptidase from the sepsis-causing pathogen Vibrio vulnificus
por: Jang, Song Yee, et al.
Publicado: (2018)

The β and γ subunits play distinct functional roles in the α(2)βγ heterotetramer of human NAD-dependent isocitrate dehydrogenase
por: Ma, Tengfei, et al.
Publicado: (2017)

Regulation of Bone Morphogenetic Protein 9 (BMP9) by Redox-dependent Proteolysis
por: Wei, Zhenquan, et al.
Publicado: (2014)

Evidence That GH115 α-Glucuronidase Activity, Which Is Required to Degrade Plant Biomass, Is Dependent on Conformational Flexibility
por: Rogowski, Artur, et al.
Publicado: (2014)

Structural and Pharmacological Characterization of Novel Potent and Selective Monoclonal Antibody Antagonists of Glucose-dependent Insulinotropic Polypeptide Receptor
por: Ravn, Peter, et al.
Publicado: (2013)

ATPase Activity and ATP-dependent Conformational Change in the Co-chaperone HSP70/HSP90-organizing Protein (HOP)
por: Yamamoto, Soh, et al.
Publicado: (2014)

Tandem sialoglycan-binding modules in a Streptococcus sanguinis serine-rich repeat adhesin create target dependent avidity effects
por: Stubbs, Haley E., et al.
Publicado: (2020)

Engineering the fragment crystallizable (Fc) region of human IgG1 multimers and monomers to fine-tune interactions with sialic acid-dependent receptors
por: Blundell, Patricia A., et al.
Publicado: (2017)

The cation diffusion facilitator protein MamM's cytoplasmic domain exhibits metal-type dependent binding modes and discriminates against Mn(2+)
por: Barber-Zucker, Shiran, et al.
Publicado: (2021)

Organization of Subunits in the Membrane Domain of the Bovine F-ATPase Revealed by Covalent Cross-linking
por: Lee, Jennifer, et al.
Publicado: (2015)

Conserved Distal Loop Residues in the Hsp104 and ClpB Middle Domain Contact Nucleotide-binding Domain 2 and Enable Hsp70-dependent Protein Disaggregation
por: DeSantis, Morgan E., et al.
Publicado: (2014)

Antibiotic binding releases autoinhibition of the TipA multidrug-resistance transcriptional regulator
por: Jiang, Xuguang, et al.
Publicado: (2020)

Crystal Structure of the Severe Acute Respiratory Syndrome (SARS) Coronavirus Nucleocapsid Protein Dimerization Domain Reveals Evolutionary Linkage between Corona- and Arteriviridae
por: Yu, I-Mei, et al.
Publicado: (2006)

Crystal Structure of Arabidopsis Deg2 Protein Reveals an Internal PDZ Ligand Locking the Hexameric Resting State
por: Sun, Renhua, et al.
Publicado: (2012)

Recombinant Severe Acute Respiratory Syndrome (SARS) Coronavirus Nucleocapsid Protein Forms a Dimer through Its C-terminal Domain
por: Yu, I-Mei, et al.
Publicado: (2005)

Cannot write session to /tmp/vufind_sessions/sess_itnkv6n3dpsd4j19tp6j4njih5