Influence of Charge, Hydrophobicity, and Size on Vitreous Pharmacokinetics of Large Molecules

PURPOSE: Development of therapeutics for retinal disease with improved durability is hampered by inadequate understanding of pharmacokinetic (PK) drivers following intravitreal injection. Previous work shows that hydrodynamic radius is correlated with vitreal half-life over the range of 3 to 7 nm, a...

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Detalles Bibliográficos
Autores principales: Crowell, Susan R., Wang, Kathryn, Famili, Amin, Shatz, Whitney, Loyet, Kelly M., Chang, Vincent, Liu, Yanqiu, Prabhu, Saileta, Kamath, Amrita V., Kelley, Robert F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2019
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6827426/
https://www.ncbi.nlm.nih.gov/pubmed/31695962
http://dx.doi.org/10.1167/tvst.8.6.1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6827426/
https://www.ncbi.nlm.nih.gov/pubmed/31695962
http://dx.doi.org/10.1167/tvst.8.6.1

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