Cargando…

Influence of Charge, Hydrophobicity, and Size on Vitreous Pharmacokinetics of Large Molecules

PURPOSE: Development of therapeutics for retinal disease with improved durability is hampered by inadequate understanding of pharmacokinetic (PK) drivers following intravitreal injection. Previous work shows that hydrodynamic radius is correlated with vitreal half-life over the range of 3 to 7 nm, a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Crowell, Susan R., Wang, Kathryn, Famili, Amin, Shatz, Whitney, Loyet, Kelly M., Chang, Vincent, Liu, Yanqiu, Prabhu, Saileta, Kamath, Amrita V., Kelley, Robert F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Association for Research in Vision and Ophthalmology 2019
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6827426/ https://www.ncbi.nlm.nih.gov/pubmed/31695962 http://dx.doi.org/10.1167/tvst.8.6.1

Ejemplares similares

Effect of molecular size on interstitial pharmacokinetics and tissue catabolism of antibodies
por: Rafidi, Hanine, et al.
Publicado: (2022)

Pharmacokinetic and Pharmacodynamic Considerations in the Design of Therapeutic Antibodies
por: Leipold, Douglas, et al.
Publicado: (2018)

Identification and characterization of an octameric PEG-protein conjugate system for intravitreal long-acting delivery to the back of the eye
por: Shatz, Whitney, et al.
Publicado: (2019)

Antibody Format and Serum Disposition Govern Ocular Pharmacokinetics of Intravenously Administered Protein Therapeutics
por: Shivva, Vittal, et al.
Publicado: (2021)

Prediction of Human Pharmacokinetics of Antibody–Drug Conjugates From Nonclinical Data
por: Li, Chunze, et al.
Publicado: (2019)

Charging of Vitreous Samples in Cryogenic Electron Microscopy Mitigated by Graphene
por: Zhang, Yue, et al.
Publicado: (2023)

Preclinical Pharmacokinetic Considerations for the Development of Antibody Drug Conjugates
por: Kamath, Amrita V., et al.
Publicado: (2014)

Vitreous pharmacokinetics and electroretinographic findings after intravitreal injection of acyclovir in rabbits
por: Damico, Francisco Max, et al.
Publicado: (2012)

In Vivo Bioavailability and Therapeutic Assessment of Host-Guest Inclusion Phenomena for the Hydrophobic Molecule Etodolac: Pharmacodynamic and Pharmacokinetic Evaluation
por: Sinha, Vivek Ranjan, et al.
Publicado: (2010)

Hydrophobicity and Charge Shape Cellular Metabolite Concentrations
por: Bar-Even, Arren, et al.
Publicado: (2011)

Charge transfer as a ubiquitous mechanism in determining the negative charge at hydrophobic interfaces
por: Poli, Emiliano, et al.
Publicado: (2020)

A script to highlight hydrophobicity and charge on protein surfaces
por: Hagemans, Dominique, et al.
Publicado: (2015)

Impact of Dendrimers on Solubility of Hydrophobic Drug Molecules
por: Choudhary, Sonam, et al.
Publicado: (2017)

Structural modulation of insulin by hydrophobic and hydrophilic molecules
por: Begum, Shahnaz, et al.
Publicado: (2023)

Semi-mechanistic Multiple-Analyte Pharmacokinetic Model for an Antibody-Drug-Conjugate in Cynomolgus Monkeys
por: Lu, Dan, et al.
Publicado: (2014)

Pharmacokinetics of heroin and its metabolites in vitreous humor and blood in a living pig model
por: Gottås, André, et al.
Publicado: (2016)

Charge and Hydrophobicity Effects of NIR Fluorophores on Bone-Specific Imaging
por: Bao, Kai, et al.
Publicado: (2015)

Diffusion and Protein Corona Formation of Lipid-Based Nanoparticles in the Vitreous Humor: Profiling and Pharmacokinetic Considerations
por: Tavakoli, Shirin, et al.
Publicado: (2020)

Vitreous Escape
por: Shanker, Hari
Publicado: (1917)

The effectiveness of laser vitreolysis for vitreous floaters in posterior vitreous detachment
por: Goh, Wan Ni, et al.
Publicado: (2022)

Population Pharmacokinetics and Pharmacodynamics of Lampalizumab Administered Intravitreally to Patients With Geographic Atrophy
por: Le, KN, et al.
Publicado: (2015)

Research on the fate of polymeric nanoparticles in the process of the intestinal absorption based on model nanoparticles with various characteristics: size, surface charge and pro-hydrophobics
por: Guo, Shiqi, et al.
Publicado: (2021)

Small-molecule fulvic acid with strong hydration ability for non-vitreous cellular cryopreservation
por: Bai, Guoying, et al.
Publicado: (2022)

Liquid Biopsy of Vitreous Reveals an Abundant Vesicle Population Consistent With the Size and Morphology of Exosomes
por: Zhao, Yuanjun, et al.
Publicado: (2018)

Polyelectrolyte Complexation of Oligonucleotides by Charged Hydrophobic—Neutral Hydrophilic Block Copolymers
por: Marras, Alexander E., et al.
Publicado: (2019)

A Comparative Study of the Second-Order Hydrophobic Moments for Globular Proteins: The Consensus Scale of Hydrophobicity and the CHARMM Partial Atomic Charges
por: Tsai, Cheng-Fang, et al.
Publicado: (2011)

Data on charge separation of bispecific and mispaired IgGs using native charge-variant mass spectrometry
por: Phung, Wilson, et al.
Publicado: (2020)

Partitioning of Small Hydrophobic Molecules into Polydimethylsiloxane in Microfluidic Analytical Devices
por: Rodrigues, Patrícia M., et al.
Publicado: (2022)

Vitreous Haemorrhage in Children
por: Shubhakaran, Khichar Purnaram
Publicado: (2015)

The Nutrition of the Lens and Vitreous
por: Smith, Henry
Publicado: (1928)

Primary vitreous cysts
por: Robben, Pieter, et al.
Publicado: (2020)

Visual prognosis and vitreous molecules after vitrectomy for macular edema with branch retinal vein occlusion
por: Noma, Hidetaka, et al.
Publicado: (2011)

Protein engineering to increase the potential of a therapeutic antibody Fab for long-acting delivery to the eye
por: Tesar, Devin, et al.
Publicado: (2017)

Microsurgical observation of the posterior vitreous in patients with vitreous hemorrhage caused by Terson syndrome
por: Hanai, Kaori, et al.
Publicado: (2020)

Changes in the vitreous body after experimental vitreous hemorrhage in rabbit: An interdisciplinary study
por: Zhang, Pengcheng, et al.
Publicado: (2023)

Peptide-Mediated Synthesis of Zeolitic Imidazolate Framework-8: Effect of Molecular Hydrophobicity, Charge Number and Charge Location
por: Tian, Maozhang, et al.
Publicado: (2021)

Pharmacokinetics and Toxicity Evaluation of a PLGA and Chitosan-Based Micro-Implant for Sustained Release of Methotrexate in Rabbit Vitreous
por: Manna, Soumyarwit, et al.
Publicado: (2021)

Charge-specific size-dependent separation of water-soluble organic molecules by fluorinated nanoporous networks
por: Byun, Jeehye, et al.
Publicado: (2016)

Invariance of molecular charge transport upon changes of extended molecule size and several related issues
por: Bâldea, Ioan
Publicado: (2016)

Amphiphilic Small-Molecule Assemblies to Enhance the Solubility and Stability of Hydrophobic Drugs
por: Gangarde, Yogesh M., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_eleqa2q6iae0dsjk2asaus0ta4