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Retinoic acid-stimulated ERK1/2 pathway regulates meiotic initiation in cultured fetal germ cells

In murine fetal germ cells, retinoic acid (RA) is an extrinsic cue for meiotic initiation that stimulates transcriptional activation of the Stimulated by retinoic acid gene 8 (Stra8), which is required for entry of germ cells into meiotic prophase I. Canonically, the biological activities of RA are...

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Detalles Bibliográficos
Autores principales: Kim, Sung-Min, Yokoyama, Toshifumi, Ng, Dylan, Ulu, Ferhat, Yamazaki, Yukiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6827903/
https://www.ncbi.nlm.nih.gov/pubmed/31682623
http://dx.doi.org/10.1371/journal.pone.0224628