Development of a new largely scalable in vitro prion propagation method for the production of infectious recombinant prions for high resolution structural studies

The resolution of the three-dimensional structure of infectious prions at the atomic level is pivotal to understand the pathobiology of Transmissible Spongiform Encephalopathies (TSE), but has been long hindered due to certain particularities of these proteinaceous pathogens. Difficulties related to...

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Detalles Bibliográficos
Autores principales: Eraña, Hasier, Charco, Jorge M., Di Bari, Michele A., Díaz-Domínguez, Carlos M., López-Moreno, Rafael, Vidal, Enric, González-Miranda, Ezequiel, Pérez-Castro, Miguel A., García-Martínez, Sandra, Bravo, Susana, Fernández-Borges, Natalia, Geijo, Mariví, D’Agostino, Claudia, Garrido, Joseba, Bian, Jifeng, König, Anna, Uluca-Yazgi, Boran, Sabate, Raimon, Khaychuk, Vadim, Vanni, Ilaria, Telling, Glenn C., Heise, Henrike, Nonno, Romolo, Requena, Jesús R., Castilla, Joaquín
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6827918/
https://www.ncbi.nlm.nih.gov/pubmed/31644574
http://dx.doi.org/10.1371/journal.ppat.1008117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6827918/
https://www.ncbi.nlm.nih.gov/pubmed/31644574
http://dx.doi.org/10.1371/journal.ppat.1008117

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