Amyloid fibrils prepared using an acetylated and methyl amidated peptide model of the α-Synuclein NAC 71–82 amino acid stretch contain an additional cross-β structure also found in prion proteins

The 71–82 fragment of the non-amyloid-β component (NAC) region of the Parkinson’s disease (PD) and dementia with Lewy bodies (DLB) related protein α-Synuclein, has been reported to be important during protein misfolding. Although reports have demonstrated the importance of this fragment for the aggr...

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Detalles Bibliográficos
Autores principales: Näsström, Thomas, Andersson, Per Ola, Lejon, Christian, Karlsson, Björn C. G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6828723/
https://www.ncbi.nlm.nih.gov/pubmed/31685848
http://dx.doi.org/10.1038/s41598-019-52206-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6828723/
https://www.ncbi.nlm.nih.gov/pubmed/31685848
http://dx.doi.org/10.1038/s41598-019-52206-5

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