ASPP2 inhibits tumor growth by repressing the mevalonate pathway in hepatocellular carcinoma

Cancer is, fundamentally, a disorder of cell growth and proliferation, which requires adequate supplies of energy and nutrients. In this study, we report that the haplo-insufficient tumor suppressor ASPP2, a p53 activator, negatively regulates the mevalonate pathway to mediate its inhibitory effect...

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Detalles Bibliográficos
Autores principales: Liang, Beibei, Chen, Rui, Song, Shaohua, Wang, Hao, Sun, Guowei, Yang, Hao, Jing, Wei, Zhou, Xuyu, Fu, Zhiren, Huang, Gang, Zhao, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6828733/
https://www.ncbi.nlm.nih.gov/pubmed/31685796
http://dx.doi.org/10.1038/s41419-019-2054-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6828733/
https://www.ncbi.nlm.nih.gov/pubmed/31685796
http://dx.doi.org/10.1038/s41419-019-2054-7

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