α-Synuclein oligomers mediate the aberrant form of spike-induced calcium release from IP(3) receptor

Emerging evidence implicates α-synuclein oligomers as potential culprits in the pathogenesis of Lewy body disease (LBD). Soluble oligomeric α-synuclein accumulation in cytoplasm is believed to modify neuronal activities and intraneural Ca(2+) dynamics, which augment the metabolic burden in central n...

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Detalles Bibliográficos
Autores principales: Yamamoto, Kenji, Izumi, Yasuhiko, Arifuku, Monami, Kume, Toshiaki, Sawada, Hideyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6828767/
https://www.ncbi.nlm.nih.gov/pubmed/31685859
http://dx.doi.org/10.1038/s41598-019-52135-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6828767/
https://www.ncbi.nlm.nih.gov/pubmed/31685859
http://dx.doi.org/10.1038/s41598-019-52135-3

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