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Essentiality of the Maltase AmlE in Maltose Utilization and Its Transcriptional Regulation by the Repressor AmlR in the Acarbose-Producing Bacterium Actinoplanes sp. SE50/110

Actinoplanes sp. SE50/110 is the wild type of industrial production strains of the fine-chemical acarbose (acarviosyl-maltose), which is used as α-glucosidase inhibitor in the treatment of type II diabetes. Although maltose is an important building block of acarbose, the maltose/maltodextrin metabol...

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Detalles Bibliográficos
Autores principales: Schaffert, Lena, Schneiker-Bekel, Susanne, Dymek, Saskia, Droste, Julian, Persicke, Marcus, Busche, Tobias, Brandt, David, Pühler, Alfred, Kalinowski, Jörn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6828939/
https://www.ncbi.nlm.nih.gov/pubmed/31736895
http://dx.doi.org/10.3389/fmicb.2019.02448