Radiosensitization of HSF-1 Knockdown Lung Cancer Cells by Low Concentrations of Hsp90 Inhibitor NVP-AUY922

The inhibition of heat shock protein 90 (Hsp90) a molecular chaperone for multiple oncogenic client proteins is considered as a promising approach to overcome radioresistance. Since most Hsp90 inhibitors activate HSF-1 that induces the transcription of cytoprotective and tumor-promoting stress prote...

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Detalles Bibliográficos
Autores principales: Kühnel, Annett, Schilling, Daniela, Combs, Stephanie E., Haller, Bernhard, Schwab, Melissa, Multhoff, Gabriele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829369/
https://www.ncbi.nlm.nih.gov/pubmed/31569342
http://dx.doi.org/10.3390/cells8101166

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829369/
https://www.ncbi.nlm.nih.gov/pubmed/31569342
http://dx.doi.org/10.3390/cells8101166

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