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Radiosensitization of HSF-1 Knockdown Lung Cancer Cells by Low Concentrations of Hsp90 Inhibitor NVP-AUY922

The inhibition of heat shock protein 90 (Hsp90) a molecular chaperone for multiple oncogenic client proteins is considered as a promising approach to overcome radioresistance. Since most Hsp90 inhibitors activate HSF-1 that induces the transcription of cytoprotective and tumor-promoting stress prote...

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Detalles Bibliográficos
Autores principales:	Kühnel, Annett, Schilling, Daniela, Combs, Stephanie E., Haller, Bernhard, Schwab, Melissa, Multhoff, Gabriele
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829369/ https://www.ncbi.nlm.nih.gov/pubmed/31569342 http://dx.doi.org/10.3390/cells8101166

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