Pyridine-Containing Macrocycles Display MMP-2/9 Inhibitory Activity and Distinct Effects on Migration and Invasion of 2D and 3D Breast Cancer Models

The role of metalloproteinases (MMPs) on the migration and invasion of cancer cells has been correlated with tumor aggressiveness, namely with the up-regulation of MMP-2 and 9. Herein, two pyridine-containing macrocyclic compounds, [15]pyN(5) and [16]pyN(5), were synthesized, chemically characterize...

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Detalles Bibliográficos
Autores principales: Proença, Susana, Antunes, Bernardo, Guedes, Rita C., Ramilo-Gomes, Filipa, Cabral, M. Fátima, Costa, Judite, Fernandes, Ana S., Castro, Matilde, Oliveira, Nuno G., Miranda, Joana P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829403/
https://www.ncbi.nlm.nih.gov/pubmed/31618886
http://dx.doi.org/10.3390/ijms20205109

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829403/
https://www.ncbi.nlm.nih.gov/pubmed/31618886
http://dx.doi.org/10.3390/ijms20205109

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