Intracellular Signals Activated by Canonical Wnt Ligands Independent of GSK3 Inhibition and β-Catenin Stabilization

In contrast to non-canonical ligands, canonical Wnts promote the stabilization of β-catenin, which is a prerequisite for formation of the TCF4/β-catenin transcriptional complex and activation of its target genes. This pathway is initiated by binding of Wnt ligands to the Frizzled/LRP5/6 receptor com...

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Detalles Bibliográficos
Autores principales: García de Herreros, Antonio, Duñach, Mireia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829497/
https://www.ncbi.nlm.nih.gov/pubmed/31557964
http://dx.doi.org/10.3390/cells8101148

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829497/
https://www.ncbi.nlm.nih.gov/pubmed/31557964
http://dx.doi.org/10.3390/cells8101148

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