Chemical Modification of Microcin J25 Reveals New Insights on the Stereospecific Requirements for Antimicrobial Activity

In this study, microcin J25, a potent antimicrobial lasso peptide that acts on Gram-negative bacteria, was subjected to a harsh treatment with a base in order to interrogate its stability and mechanism of action and explore its structure-activity relationship. Despite the high stability reported for...

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Detalles Bibliográficos
Autores principales: Martin-Gómez, Helena, Jorba, Marta, Albericio, Fernando, Viñas, Miguel, Tulla-Puche, Judit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829517/
https://www.ncbi.nlm.nih.gov/pubmed/31627419
http://dx.doi.org/10.3390/ijms20205152

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829517/
https://www.ncbi.nlm.nih.gov/pubmed/31627419
http://dx.doi.org/10.3390/ijms20205152

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