An anti-CRF antibody suppresses the HPA axis and reverses stress-induced phenotypes

Hypothalamic–pituitary–adrenal (HPA) axis dysfunction contributes to numerous human diseases and disorders. We developed a high-affinity monoclonal antibody, CTRND05, targeting corticotropin-releasing factor (CRF). In mice, CTRND05 blocks stress-induced corticosterone increases, counteracts effects...

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Detalles Bibliográficos
Autores principales: Futch, Hunter S., McFarland, Karen N., Moore, Brenda D., Kuhn, M. Zino, Giasson, Benoit I., Ladd, Thomas B., Scott, Karen A., Shapiro, Melanie R., Nosacka, Rachel L., Goodwin, Marshall S., Ran, Yong, Cruz, Pedro E., Ryu, Daniel H., Croft, Cara L., Levites, Yona, Janus, Christopher, Chakrabarty, Paramita, Judge, Andrew R., Brusko, Todd M., de Kloet, Annette D., Krause, Eric G., Golde, Todd E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829597/
https://www.ncbi.nlm.nih.gov/pubmed/31467037
http://dx.doi.org/10.1084/jem.20190430

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829597/
https://www.ncbi.nlm.nih.gov/pubmed/31467037
http://dx.doi.org/10.1084/jem.20190430

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