Tumors with TSC mutations are sensitive to CDK7 inhibition through NRF2 and glutathione depletion

Tuberous sclerosis complex (TSC) is characterized by tumor development in the brain, heart, kidney, and lungs. In TSC tumors, loss of the TSC1/TSC2 protein complex leads to activation of mTORC1 with downstream effects on anabolism and cell growth. Because mTORC1 activation enhances mRNA transcriptio...

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Detalles Bibliográficos
Autores principales: Zarei, Mahsa, Du, Heng, Nassar, Amin H., Yan, Rachel E., Giannikou, Krinio, Johnson, Sneha H., Lam, Hilaire C., Henske, Elizabeth P., Wang, Yubao, Zhang, Tinghu, Asara, John, Kwiatkowski, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829598/
https://www.ncbi.nlm.nih.gov/pubmed/31506280
http://dx.doi.org/10.1084/jem.20190251

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829598/
https://www.ncbi.nlm.nih.gov/pubmed/31506280
http://dx.doi.org/10.1084/jem.20190251

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