Modular Synthesis of Di- and Trisubstituted Imidazoles from Ketones and Aldehydes: A Route to Kinase Inhibitors

[Image: see text] A one-pot and modular approach to the synthesis of 2,4(5)-disubstituted imidazoles was developed based on ketone oxidation, employing catalytic HBr and DMSO, followed by imidazole condensation with aldehydes. This methodology afforded twenty-nine disubstituted NH-imidazoles (23%–85...

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Detalles Bibliográficos
Autores principales: de Toledo, Ian, Grigolo, Thiago A., Bennett, James M., Elkins, Jonathan M., Pilli, Ronaldo A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829625/
https://www.ncbi.nlm.nih.gov/pubmed/31460764
http://dx.doi.org/10.1021/acs.joc.9b01844

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829625/
https://www.ncbi.nlm.nih.gov/pubmed/31460764
http://dx.doi.org/10.1021/acs.joc.9b01844

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