The PI(4)P phosphatase Sac2 controls insulin granule docking and release

Insulin granule biogenesis involves transport to, and stable docking at, the plasma membrane before priming and fusion. Defects in this pathway result in impaired insulin secretion and are a hallmark of type 2 diabetes. We now show that the phosphatidylinositol 4-phosphate phosphatase Sac2 localizes...

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Detalles Bibliográficos
Autores principales: Nguyen, Phuoc My, Gandasi, Nikhil R., Xie, Beichen, Sugahara, Sari, Xu, Yingke, Idevall-Hagren, Olof
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829663/
https://www.ncbi.nlm.nih.gov/pubmed/31533953
http://dx.doi.org/10.1083/jcb.201903121

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829663/
https://www.ncbi.nlm.nih.gov/pubmed/31533953
http://dx.doi.org/10.1083/jcb.201903121

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