Cargando…

The PI(4)P phosphatase Sac2 controls insulin granule docking and release

Insulin granule biogenesis involves transport to, and stable docking at, the plasma membrane before priming and fusion. Defects in this pathway result in impaired insulin secretion and are a hallmark of type 2 diabetes. We now show that the phosphatidylinositol 4-phosphate phosphatase Sac2 localizes...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nguyen, Phuoc My, Gandasi, Nikhil R., Xie, Beichen, Sugahara, Sari, Xu, Yingke, Idevall-Hagren, Olof
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2019
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829663/ https://www.ncbi.nlm.nih.gov/pubmed/31533953 http://dx.doi.org/10.1083/jcb.201903121

Ejemplares similares

Insulin granule biogenesis and exocytosis
por: Omar-Hmeadi, Muhmmad, et al.
Publicado: (2020)

The endoplasmic reticulum–plasma membrane tethering protein TMEM24 is a regulator of cellular Ca(2+) homeostasis
por: Xie, Beichen, et al.
Publicado: (2021)

The β-cell primary cilium is an autonomous Ca(2+) compartment for paracrine GABA signaling
por: Sanchez, Gonzalo Manuel, et al.
Publicado: (2022)

Identification of Inhibitors of Inositol 5-Phosphatases through Multiple Screening Strategies
por: Pirruccello, Michelle, et al.
Publicado: (2014)

Statistical Frailty Modeling for Quantitative Analysis of Exocytotic Events Recorded by Live Cell Imaging: Rapid Release of Insulin-Containing Granules Is Impaired in Human Diabetic β-cells
por: Cortese, Giuliana, et al.
Publicado: (2016)

Setting the Stage for Insulin Granule Dysfunction during Type-1-Diabetes: Is ER Stress the Culprit?
por: Makam, Aishwarya A., et al.
Publicado: (2022)

Metabolic stress-induced human beta-cell death is mediated by increased intracellular levels of adenosine
por: Ngamjariyawat, Anongnad, et al.
Publicado: (2023)

Granuphilin molecularly docks insulin granules to the fusion machinery
por: Gomi, Hiroshi, et al.
Publicado: (2005)

Ca(2+) channel clustering with insulin-containing granules is disturbed in type 2 diabetes
por: Gandasi, Nikhil R., et al.
Publicado: (2017)

Piezo1 activation attenuates thrombin-induced blebbing in breast cancer cells
por: O'Callaghan, Paul, et al.
Publicado: (2022)

Survey of Red Fluorescence Proteins as Markers for Secretory Granule Exocytosis
por: Gandasi, Nikhil R., et al.
Publicado: (2015)

Functions and Mechanisms of SAC Phosphoinositide Phosphatases in Plants
por: Mao, Yanbo, et al.
Publicado: (2021)

Syntaxin clusters at secretory granules in a munc18-bound conformation
por: Yin, Peng, et al.
Publicado: (2018)

Fusion pore regulation by cAMP/Epac2 controls cargo release during insulin exocytosis
por: Guček, Alenka, et al.
Publicado: (2019)

Osh6 Revisited: Control of PS Transport by the Concerted Actions of PI4P and Sac1 Phosphatase
por: Eisenreichova, Andrea, et al.
Publicado: (2021)

SUMOylation Regulates Insulin Exocytosis Downstream of Secretory Granule Docking in Rodents and Humans
por: Dai, Xiao-Qing, et al.
Publicado: (2011)

Allosteric Activation of the Phosphoinositide Phosphatase Sac1 by Anionic Phospholipids
por: Zhong, Shurong, et al.
Publicado: (2012)

Cellular homeostasis in the Drosophila retina requires the lipid phosphatase Sac1
por: Griffiths, Nigel W., et al.
Publicado: (2020)

Syntaxins on granules promote docking of granules via interactions with munc18
por: Borisovska, Maria
Publicado: (2018)

Integration of Golgi trafficking and growth factor signaling by the lipid phosphatase SAC1
por: Blagoveshchenskaya, Anastasia, et al.
Publicado: (2008)

The First Transmembrane Domain of Lipid Phosphatase SAC1 Promotes Golgi Localization
por: Wang, Jinzhi, et al.
Publicado: (2013)

Nanoscale Amperometry Reveals that Only a Fraction of Vesicular Serotonin Content is Released During Exocytosis from Beta Cells
por: Hatamie, Amir, et al.
Publicado: (2021)

Expression of yeast lipid phosphatase Sac1p is regulated by phosphatidylinositol-4-phosphate
por: Knödler, Andreas, et al.
Publicado: (2008)

Sac2/INPP5F is an inositol 4-phosphatase that functions in the endocytic pathway
por: Nakatsu, Fubito, et al.
Publicado: (2015)

In pancreatic islets from type 2 diabetes patients, the dampened circadian oscillators lead to reduced insulin and glucagon exocytosis
por: Petrenko, Volodymyr, et al.
Publicado: (2020)

There Is Something About Insulin Granules
por: Roep, Bart O.
Publicado: (2020)

Inside the Insulin Secretory Granule
por: Germanos, Mark, et al.
Publicado: (2021)

PI(4)P gets Sac-rificed in the name of endocytic recycling
por: Short, Ben
Publicado: (2015)

The proteome of the human endolymphatic sac endolymph
por: Ölander, Christine, et al.
Publicado: (2021)

ASSOCIATION OF THE ALKALINE PHOSPHATASE OF RABBIT POLYMORPHONUCLEAR LEUKOCYTES WITH THE MEMBRANE OF THE SPECIFIC GRANULES
por: Bretz, Ursula, et al.
Publicado: (1973)

Granuphilin exclusively mediates functional granule docking to the plasma membrane
por: Mizuno, Kouichi, et al.
Publicado: (2016)

MiR‐335 overexpression impairs insulin secretion through defective priming of insulin vesicles
por: Salunkhe, Vishal A., et al.
Publicado: (2017)

Decreased phosphatase PTEN amplifies PI3K signaling and enhances proinflammatory cytokine release in COPD
por: Yanagisawa, Satoru, et al.
Publicado: (2017)

Munc18c mediates exocytosis of pre-docked and newcomer insulin granules underlying biphasic glucose stimulated insulin secretion in human pancreatic beta-cells
por: Zhu, Dan, et al.
Publicado: (2015)

Covalent Docking Predicts Substrates for Haloalkanoate Dehalogenase Superfamily Phosphatases
por: London, Nir, et al.
Publicado: (2014)

ISOLATION OF AN INSULIN SECRETION GRANULE FRACTION
por: Lindall, Arnold W., et al.
Publicado: (1963)

Isolation and Proteomics of the Insulin Secretory Granule
por: Norris, Nicholas, et al.
Publicado: (2021)

Local control of phosphatidylinositol 4-phosphate signaling in the Golgi apparatus by Vps74 and Sac1 phosphoinositide phosphatase
por: Wood, Christopher S., et al.
Publicado: (2012)

LOCALIZATION OF ESTERASE AND ACID PHOSPHATASE IN GRANULES AND COLLOID DROPLETS IN RAT THYROID EPITHELIUM
por: Wollman, Seymour H., et al.
Publicado: (1964)

Primary Teratoma of the Lesser Sac: Lesser Sac Teratoma
por: Hardesty, Brandon M., et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_c9l30462vl0ens59j84726kv02