Detection of fetal trisomy and single gene disease by massively parallel sequencing of extracellular vesicle DNA in maternal plasma: a proof-of-concept validation

BACKGROUND: During human pregnancy, placental trophectoderm cells release extracellular vesicles (EVs) into maternal circulation. Trophoblasts also give rise to cell-free DNA (cfDNA) in maternal blood, and has been used for noninvasive prenatal screening for chromosomal aneuploidy. We intended to pr...

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Detalles Bibliográficos
Autores principales: Zhang, Weiting, Lu, Sen, Pu, Dandan, Zhang, Haiping, Yang, Lin, Zeng, Peng, Su, Fengxia, Chen, Zhichao, Guo, Mei, Gu, Ying, Luo, Yanmei, Hu, Huamei, Lu, Yanping, Chen, Fang, Gao, Ya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829814/
https://www.ncbi.nlm.nih.gov/pubmed/31684971
http://dx.doi.org/10.1186/s12920-019-0590-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829814/
https://www.ncbi.nlm.nih.gov/pubmed/31684971
http://dx.doi.org/10.1186/s12920-019-0590-8

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