Inhibition of JAK-STAT Signaling with Baricitinib Reduces Inflammation and Improves Cellular Homeostasis in Progeria Cells

Hutchinson-Gilford progeria syndrome (HGPS), a rare premature aging disorder that leads to death at an average age of 14.7 years due to myocardial infarction or stroke, is caused by mutations in the LMNA gene. Nearly 90% of HGPS cases carry the G608G mutation within exon 11 that generates a truncate...

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Detalles Bibliográficos
Autores principales: Liu, Chang, Arnold, Rouven, Henriques, Gonçalo, Djabali, Karima
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829898/
https://www.ncbi.nlm.nih.gov/pubmed/31635416
http://dx.doi.org/10.3390/cells8101276

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829898/
https://www.ncbi.nlm.nih.gov/pubmed/31635416
http://dx.doi.org/10.3390/cells8101276

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