Cargando…

The impact of hepatocyte nuclear factor-1α on liver malignancies and cell stemness with metabolic consequences

Hepatocyte nuclear factor-1 alpha (HNF-1α) is a transcription factor expressed predominantly in the liver among other organs. Structurally, it contains POU-homeodomain that binds to DNA and form proteins that help in maintaining cellular homeostasis, controlling metabolism, and differentiating cell...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Xue, Hassan, Waseem, Zhao, Jing, Bakht, Sahar, Nie, Yunjuan, Wang, Ying, Pang, Qingfeng, Huang, Zhaohui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829964/ https://www.ncbi.nlm.nih.gov/pubmed/31685031 http://dx.doi.org/10.1186/s13287-019-1438-z

Ejemplares similares

Immunometabolism features of metabolic deregulation and cancer
por: Wang, Xue, et al.
Publicado: (2018)

H19 Is Expressed in Hybrid Hepatocyte Nuclear Factor 4α(+) Periportal Hepatocytes but Not Cytokeratin 19(+) Cholangiocytes in Cholestatic Livers
por: Jiang, YanChao, et al.
Publicado: (2018)

Hepatocyte nuclear factor 4α in the pathogenesis of non-alcoholic fatty liver disease
por: Pan, Xiaoli, et al.
Publicado: (2022)

The role of hepatocyte nuclear factor 4α (HNF4α) in tumorigenesis
por: Sang, Lei, et al.
Publicado: (2022)

Controversial roles of hepatocyte nuclear receptor 4 α on tumorigenesis
por: Wang, Zhu, et al.
Publicado: (2021)

Sirtuin 2 Prevents Liver Steatosis and Metabolic Disorders by Deacetylation of Hepatocyte Nuclear Factor 4α
por: Ren, Huihui, et al.
Publicado: (2021)

Feedback loop between hepatocyte nuclear factor 1α and endoplasmic reticulum stress mitigates liver injury by downregulating hepatocyte apoptosis
por: Liu, Si-Ying, et al.
Publicado: (2022)

Hepatocyte nuclear factor 4α negatively regulates connective tissue growth factor during liver regeneration
por: Zhou, Junmei, et al.
Publicado: (2020)

Inherent growth advantage of (pre)malignant hepatocytes associated with nuclear translocation of pro-transforming growth factor α
por: Schausberger, E, et al.
Publicado: (2004)

Hepatocyte Nuclear Factor 4α Controls Iron Metabolism and Regulates Transferrin Receptor 2 in Mouse Liver
por: Matsuo, Shunsuke, et al.
Publicado: (2015)

Induction of Highly Functional Hepatocytes from Human Umbilical Cord Mesenchymal Stem Cells by HNF4α Transduction
por: Hang, Hualian, et al.
Publicado: (2014)

Nuclear ErbB2 expression in hepatocytes in liver disease
por: Döring, Paula, et al.
Publicado: (2020)

Expression profile analysis of the inflammatory response regulated by hepatocyte nuclear factor 4α
por: Wang, Zhongyan, et al.
Publicado: (2011)

Complex Interplay between the Lipin 1 and the Hepatocyte Nuclear Factor 4 α (HNF4α) Pathways to Regulate Liver Lipid Metabolism
por: Chen, Zhouji, et al.
Publicado: (2012)

Serum transferrin as a biomarker of hepatocyte nuclear factor 4 alpha activity and hepatocyte function in liver diseases
por: Guldiken, Nurdan, et al.
Publicado: (2021)

Hepatocyte Nuclear Factor 1α Proinflammatory Effect Linked to the Overexpression of Liver Nuclear Factor–κB in Experimental Model of Chronic Kidney Disease
por: Sucajtys-Szulc, Elzbieta, et al.
Publicado: (2022)

The nuclear receptor hepatocyte nuclear factor 4α acts as a morphogen to induce the formation of microvilli
por: Chiba, Hideki, et al.
Publicado: (2006)

Mesenchymal stem cells overexpressing hepatocyte nuclear factor-4 alpha alleviate liver injury by modulating anti-inflammatory functions in mice
por: Ye, Zhenxiong, et al.
Publicado: (2019)

Role of hepatocyte nuclear factor 4-alpha in gastrointestinal and liver diseases
por: Yeh, Matthew M, et al.
Publicado: (2019)

Hepatocyte Nuclear Factor 1α Controls the Expression of Terminal Complement Genes
por: Pontoglio, Marco, et al.
Publicado: (2001)

Hepatocyte Nuclear Factor 1α-Mutated Hepatocellular Adenomas: An Atypical Presentation
por: Sousa, Camila Maria Neves, et al.
Publicado: (2017)

Carboxylesterase 1 Is Regulated by Hepatocyte Nuclear Factor 4α and Protects Against Alcohol- and MCD diet-induced Liver Injury
por: Xu, Jiesi, et al.
Publicado: (2016)

Crystallization of hepatocyte nuclear factor 4α (HNF4α) in complex with the HNF1α promoter element
por: Lu, Peng, et al.
Publicado: (2008)

Human Pluripotent Stem Cell-Derived Hepatocyte-Like Cells and Organoids for Liver Disease and Therapy
por: Li, Yang, et al.
Publicado: (2021)

Developmental Regulation of Hepatitis B Virus Biosynthesis by Hepatocyte Nuclear Factor 4α
por: Li, Lie, et al.
Publicado: (2009)

Hepatocyte nuclear factor 4α regulates megalin expression in proximal tubular cells
por: Sasaki, Shota, et al.
Publicado: (2018)

SAT-162 Hepatocyte Nuclear Factor-4α (HNF44α) as a Target to Treat DM
por: Jorge dos Santos, Gustavo, et al.
Publicado: (2019)

In vitro culture of isolated primary hepatocytes and stem cell-derived hepatocyte-like cells for liver regeneration
por: Hu, Chenxia, et al.
Publicado: (2015)

Hepatocyte Nuclear Factor 4α (HNF4α) Plays a Controlling Role in Expression of the Retinoic Acid Receptor β (RARβ) Gene in Hepatocytes
por: Zolfaghari, Reza, et al.
Publicado: (2023)

Regulation of Hepatocyte Nuclear Factor 4α Attenuated Lipotoxicity but Increased Bile Acid Toxicity in Non-Alcoholic Fatty Liver Disease
por: Roh, Yoon Jin, et al.
Publicado: (2022)

Mesenchymal Stem Cell-Derived Hepatocytes for Functional Liver Replacement
por: Christ, Bruno, et al.
Publicado: (2012)

Hepatocellular carcinoma: from hepatocyte to liver cancer stem cell
por: Karakasiliotis, Ioannis, et al.
Publicado: (2015)

The Effects of Conditioned Medium Derived from Mesenchymal Stem Cells Cocultured with Hepatocytes on Damaged Hepatocytes and Acute Liver Failure in Rats
por: Chen, Li, et al.
Publicado: (2018)

Nonalcoholic Lipid Accumulation and Hepatocyte Malignant Transformation
por: Gu, Juanjuan, et al.
Publicado: (2016)

Localization of hepatocyte nuclear factor‐4α in the nucleolus and nucleus is regulated by its C‐terminus
por: Ogata, Makiko, et al.
Publicado: (2012)

Clustering Nuclear Receptors in Liver Regeneration Identifies Candidate Modulators of Hepatocyte Proliferation and Hepatocarcinoma
por: Vacca, Michele, et al.
Publicado: (2014)

Transcriptional Regulation of the Angptl8 Gene by Hepatocyte Nuclear Factor-1 in the Murine Liver
por: Watanabe, Takuya, et al.
Publicado: (2020)

Hepatocyte Nuclear Factor-1α Increases Fibrinogen Gene Expression in Liver and Plasma Fibrinogen Concentration in Rats with Experimental Chronic Renal Failure
por: Sucajtys-Szulc, Elzbieta, et al.
Publicado: (2023)

Modeling Human Liver Biology Using Stem Cell-Derived Hepatocytes
por: Sun, Pingnan, et al.
Publicado: (2013)

Concurrent isolation of hepatic stem cells and hepatocytes from the human liver
por: Lee, Serene M. L., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_jnlsir16nalmahrcnmsif32tto