Evaluation of human primary intestinal monolayers for drug metabolizing capabilities

BACKGROUND: The intestinal epithelium is a major site of drug metabolism in the human body, possessing enterocytes that house brush border enzymes and phase I and II drug metabolizing enzymes (DMEs). The enterocytes are supported by a porous extracellular matrix (ECM) that enables proper cell adhesi...

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Detalles Bibliográficos
Autores principales: Speer, Jennifer E., Wang, Yuli, Fallon, John K., Smith, Philip C., Allbritton, Nancy L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829970/
https://www.ncbi.nlm.nih.gov/pubmed/31709009
http://dx.doi.org/10.1186/s13036-019-0212-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829970/
https://www.ncbi.nlm.nih.gov/pubmed/31709009
http://dx.doi.org/10.1186/s13036-019-0212-1

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