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Interplay between Metabolites and the Epigenome in Regulating Embryonic and Adult Stem Cell Potency and Maintenance
The environment surrounding stem cells has the ability to elicit profound, heritable epigenetic changes orchestrated by multiple epigenetic mechanisms, which can be modulated by the level of specific metabolites. In this review, we highlight the significance of metabolism in regulating stem cell hom...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6830055/ https://www.ncbi.nlm.nih.gov/pubmed/31597110 http://dx.doi.org/10.1016/j.stemcr.2019.09.003 |
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author | Harvey, Alexandra Caretti, Giuseppina Moresi, Viviana Renzini, Alessandra Adamo, Sergio |
author_facet | Harvey, Alexandra Caretti, Giuseppina Moresi, Viviana Renzini, Alessandra Adamo, Sergio |
author_sort | Harvey, Alexandra |
collection | PubMed |
description | The environment surrounding stem cells has the ability to elicit profound, heritable epigenetic changes orchestrated by multiple epigenetic mechanisms, which can be modulated by the level of specific metabolites. In this review, we highlight the significance of metabolism in regulating stem cell homeostasis, cell state, and differentiation capacity, using metabolic regulation of embryonic and adult muscle stem cells as examples, and cast light on the interaction between cellular metabolism and epigenetics. These new regulatory networks, based on the dynamic interplay between metabolism and epigenetics in stem cell biology, are important, not only for understanding tissue homeostasis, but to determine in vitro culture conditions which accurately support normal cell physiology. |
format | Online Article Text |
id | pubmed-6830055 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-68300552019-11-07 Interplay between Metabolites and the Epigenome in Regulating Embryonic and Adult Stem Cell Potency and Maintenance Harvey, Alexandra Caretti, Giuseppina Moresi, Viviana Renzini, Alessandra Adamo, Sergio Stem Cell Reports Review The environment surrounding stem cells has the ability to elicit profound, heritable epigenetic changes orchestrated by multiple epigenetic mechanisms, which can be modulated by the level of specific metabolites. In this review, we highlight the significance of metabolism in regulating stem cell homeostasis, cell state, and differentiation capacity, using metabolic regulation of embryonic and adult muscle stem cells as examples, and cast light on the interaction between cellular metabolism and epigenetics. These new regulatory networks, based on the dynamic interplay between metabolism and epigenetics in stem cell biology, are important, not only for understanding tissue homeostasis, but to determine in vitro culture conditions which accurately support normal cell physiology. Elsevier 2019-10-08 /pmc/articles/PMC6830055/ /pubmed/31597110 http://dx.doi.org/10.1016/j.stemcr.2019.09.003 Text en © 2019 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review Harvey, Alexandra Caretti, Giuseppina Moresi, Viviana Renzini, Alessandra Adamo, Sergio Interplay between Metabolites and the Epigenome in Regulating Embryonic and Adult Stem Cell Potency and Maintenance |
title | Interplay between Metabolites and the Epigenome in Regulating Embryonic and Adult Stem Cell Potency and Maintenance |
title_full | Interplay between Metabolites and the Epigenome in Regulating Embryonic and Adult Stem Cell Potency and Maintenance |
title_fullStr | Interplay between Metabolites and the Epigenome in Regulating Embryonic and Adult Stem Cell Potency and Maintenance |
title_full_unstemmed | Interplay between Metabolites and the Epigenome in Regulating Embryonic and Adult Stem Cell Potency and Maintenance |
title_short | Interplay between Metabolites and the Epigenome in Regulating Embryonic and Adult Stem Cell Potency and Maintenance |
title_sort | interplay between metabolites and the epigenome in regulating embryonic and adult stem cell potency and maintenance |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6830055/ https://www.ncbi.nlm.nih.gov/pubmed/31597110 http://dx.doi.org/10.1016/j.stemcr.2019.09.003 |
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