Cargando…

Capsaicin Targets tNOX (ENOX2) to Inhibit G1 Cyclin/CDK Complex, as Assessed by the Cellular Thermal Shift Assay (CETSA)

Capsaicin (8-methyl-N-vanillyl-6-noneamide), which is an active component in red chili peppers, is used as a chemopreventive agent that shows favorable cytotoxicity against cancer cells. Accumulating evidence indicates that capsaicin preferentially inhibits a tumor-associated NADH oxidase (tNOX, ENO...

Descripción completa

Detalles Bibliográficos
Autores principales:	Islam, Atikul, Su, Ally J., Zeng, Zih-Ming, Chueh, Pin Ju, Lin, Ming-Hung
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6830080/ https://www.ncbi.nlm.nih.gov/pubmed/31635402 http://dx.doi.org/10.3390/cells8101275

Ejemplares similares

Engagement with tNOX (ENOX2) to Inhibit SIRT1 and Activate p53-Dependent and -Independent Apoptotic Pathways by Novel 4,11-Diaminoanthra[2,3-b]furan-5,10-diones in Hepatocellular Carcinoma Cells
por: Lin, Chia-Yang, et al.
Publicado: (2019)

Regulation of tNOX expression through the ROS-p53-POU3F2 axis contributes to cellular responses against oxaliplatin in human colon cancer cells
por: Chen, Huei-Yu, et al.
Publicado: (2018)

Capsaicin Inhibits Multiple Bladder Cancer Cell Phenotypes by Inhibiting Tumor-Associated NADH Oxidase (tNOX) and Sirtuin1 (SIRT1)
por: Lin, Ming-Hung, et al.
Publicado: (2016)

Bis(chloroacetamidino)-Derived Heteroarene-Fused Anthraquinones Bind to and Cause Proteasomal Degradation of tNOX, Leading to c-Flip Downregulation and Apoptosis in Oral Cancer Cells
por: Chang, Jeng Shiun, et al.
Publicado: (2022)

Capsaicin Inhibited Aggressive Phenotypes through Downregulation of Tumor-Associated NADH Oxidase (tNOX) by POU Domain Transcription Factor POU3F2
por: Chen, Hung Yen, et al.
Publicado: (2016)

Tumor-associated NADH oxidase (tNOX)-NAD(+)-sirtuin 1 axis contributes to oxaliplatin-induced apoptosis of gastric cancer cells
por: Chen, Huei-Yu, et al.
Publicado: (2017)

Current Advances in CETSA
por: Tolvanen, Tuomas Aleksi
Publicado: (2022)

A widely-applicable high-throughput cellular thermal shift assay (CETSA) using split Nano Luciferase
por: Martinez, Natalia J., et al.
Publicado: (2018)

The use of cellular thermal shift assay (CETSA) to study Crizotinib resistance in ALK-expressing human cancers
por: Alshareef, Abdulraheem, et al.
Publicado: (2016)

Benzo[b]thiophenesulphonamide 1,1-dioxide derivatives inhibit tNOX activity in a redox state-dependent manner
por: Encío, I, et al.
Publicado: (2005)

ENOX2 Target for the Anticancer Isoflavone ME-143
por: Morré, D. James, et al.
Publicado: (2014)

Monitoring structural modulation of redox-sensitive proteins in cells with MS-CETSA
por: Sun, Wendi, et al.
Publicado: (2019)

CETSA-based target engagement of taxanes as biomarkers for efficacy and resistance
por: Langebäck, Anette, et al.
Publicado: (2019)

Targeting Enox1 in tumor stroma increases the efficacy of fractionated radiotherapy
por: Smith, Clayton A., et al.
Publicado: (2016)

Identification of antimalarial targets of chloroquine by a combined deconvolution strategy of ABPP and MS-CETSA
por: Gao, Peng, et al.
Publicado: (2022)

Cyclin K goes with Cdk12 and Cdk13
por: Kohoutek, Jiri, et al.
Publicado: (2012)

Molecular docking analysis of piperine with CDK2,CDK4,Cyclin D and Cyclin T proteins
por: Rekha, Umapathy Vidhya, et al.
Publicado: (2020)

CETSA quantitatively verifies in vivo target engagement of novel RIPK1 inhibitors in various biospecimens
por: Ishii, Tsuyoshi, et al.
Publicado: (2017)

CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil
por: Almqvist, Helena, et al.
Publicado: (2016)

Nuclear Import of Cdk/Cyclin Complexes: Identification of Distinct Mechanisms for Import of Cdk2/Cyclin E and Cdc2/Cyclin B1
por: Moore, Jonathan D., et al.
Publicado: (1999)

Cell cycle progression mechanisms: slower cyclin-D/CDK4 activation and faster cyclin-E/CDK2
por: Zhang, Wengang, et al.
Publicado: (2023)

Positioning High-Throughput CETSA in Early Drug Discovery through Screening against B-Raf and PARP1
por: Shaw, Joseph, et al.
Publicado: (2018)

Comparison of deregulated expression of cyclin D1 and cyclin E with that of cyclin-dependent kinase 4 (CDK4) and CDK2 in human oesophageal squamous cell carcinoma
por: Matsumoto, M, et al.
Publicado: (1999)

Cyclin B/CDK1 and Cyclin A/CDK2 phosphorylate DENR to promote mitotic protein translation and faithful cell division
por: Clemm von Hohenberg, Katharina, et al.
Publicado: (2022)

ENOX2-based early detection (ONCOblot) of asbestos-induced malignant mesothelioma 4–10 years in advance of clinical symptoms
por: Morré, D. James, et al.
Publicado: (2016)

Phylogenetic analysis of CDK and cyclin proteins in premetazoan lineages
por: Cao, Lihuan, et al.
Publicado: (2014)

Structural insights into the functional diversity of the CDK–cyclin family
por: Wood, Daniel J., et al.
Publicado: (2018)

The awakening of the CDK10/Cyclin M protein kinase
por: Guen, Vincent J., et al.
Publicado: (2017)

Lineage specific composition of cyclin D–CDK4/CDK6–p27 complexes reveals distinct functions of CDK4, CDK6 and individual D‐type cyclins in differentiating cells of embryonic origin
por: Bryja, V., et al.
Publicado: (2008)

Erratum to: ENOX2-based early detection (ONCOblot) of asbestos-induced malignant mesothelioma 4–10 years in advance of clinical symptoms
por: Morré, D. James, et al.
Publicado: (2016)

ENOX2 NADH Oxidase: A BCR-ABL1-Dependent Cell Surface and Secreted Redox Protein in Chronic Myeloid Leukemia
por: Baykal, Seda, et al.
Publicado: (2023)

The CDK Subunit CKS2 Counteracts CKS1 to Control Cyclin A/CDK2 Activity in Maintaining Replicative Fidelity and Neurodevelopment
por: Frontini, Mattia, et al.
Publicado: (2012)

The Cyclin-dependent Kinase Cdk2 Regulates Thymocyte Apoptosis
por: Hakem, Anne, et al.
Publicado: (1999)

Rising Cyclin-CDK Levels Order Cell Cycle Events
por: Oikonomou, Catherine, et al.
Publicado: (2011)

The structure and substrate specificity of human Cdk12/Cyclin K
por: Bösken, Christian A., et al.
Publicado: (2014)

Cyclin-dependent kinases and CDK inhibitors in virus-associated cancers
por: Tavakolian, Shaian, et al.
Publicado: (2020)

Cyclin-Dependent Kinases (CDK) and Their Role in Diseases Development–Review
por: Łukasik, Paweł, et al.
Publicado: (2021)

Functional characterization of the human Cdk10/Cyclin Q complex
por: Düster, Robert, et al.
Publicado: (2022)

Temporal changes in cyclinD-CDK4/CDK6 and cyclinE-CDK2 pathways: implications for the mechanism of deficient decidualization in an immune-based mouse model of unexplained recurrent spontaneous abortion
por: Chang, Zhuo, et al.
Publicado: (2022)

Caenorhabditis elegans Cyclin D/CDK4 and Cyclin E/CDK2 Induce Distinct Cell Cycle Re-Entry Programs in Differentiated Muscle Cells
por: Korzelius, Jerome, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_vj4425ef0nl0fg0icdh6ri06ib