Cargando…

The E-Cadherin and N-Cadherin Switch in Epithelial-to-Mesenchymal Transition: Signaling, Therapeutic Implications, and Challenges

Epithelial-to-Mesenchymal Transition (EMT) has been shown to be crucial in tumorigenesis where the EMT program enhances metastasis, chemoresistance and tumor stemness. Due to its emerging role as a pivotal driver of tumorigenesis, targeting EMT is of great therapeutic interest in counteracting metas...

Descripción completa

Detalles Bibliográficos
Autores principales:	Loh, Chin-Yap, Chai, Jian Yi, Tang, Ting Fang, Wong, Won Fen, Sethi, Gautam, Shanmugam, Muthu Kumaraswamy, Chong, Pei Pei, Looi, Chung Yeng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6830116/ https://www.ncbi.nlm.nih.gov/pubmed/31547193 http://dx.doi.org/10.3390/cells8101118

Ejemplares similares

E-cadherin on epithelial–mesenchymal transition in thyroid cancer
por: Zhu, Xiaoyu, et al.
Publicado: (2021)

Role of N-Cadherin in Epithelial-to-Mesenchymal Transition and Chemosensitivity of Colon Carcinoma Cells
por: Skarkova, Veronika, et al.
Publicado: (2022)

Distinct Mesenchymal Alterations in N-Cadherin and E-Cadherin Positive Primary Renal Epithelial Cells
por: Keller, Christof, et al.
Publicado: (2012)

Tension Monitoring during Epithelial-to-Mesenchymal Transition Links the Switch of Phenotype to Expression of Moesin and Cadherins in NMuMG Cells
por: Schneider, David, et al.
Publicado: (2013)

Role of epithelial-mesenchymal transition markers E-cadherin, N-cadherin, β-catenin and ZEB2 in laryngeal squamous cell carcinoma
por: Zhu, Guang-Jie, et al.
Publicado: (2018)

VEGF Mediates Tumor Growth and Metastasis by Affecting the Expression of E-Cadherin and N-Cadherin Promoting Epithelial to Mesenchymal Transition in Gastric Cancer
por: Zhang, Yue, et al.
Publicado: (2023)

E/N-cadherin switch mediates cancer progression via TGF-β-induced epithelial-to-mesenchymal transition in extrahepatic cholangiocarcinoma
por: Araki, K, et al.
Publicado: (2011)

Signal Transducer and Activator of Transcription (STATs) Proteins in Cancer and Inflammation: Functions and Therapeutic Implication
por: Loh, Chin-Yap, et al.
Publicado: (2019)

N-Cadherin Extracellular Repeat 4 Mediates Epithelial to Mesenchymal Transition and Increased Motility
por: Kim, Jae-Beom, et al.
Publicado: (2000)

Loss of E-cadherin and epithelial to mesenchymal transition is not required for cell motility in tissues or for metastasis
por: Liu, Xiang, et al.
Publicado: (2014)

Roles of E-cadherin and Noncoding RNAs in the Epithelial–mesenchymal Transition and Progression in Gastric Cancer
por: Bure, Irina V., et al.
Publicado: (2019)

Significance of E-cadherin and Vimentin as epithelial-mesenchymal transition markers in colorectal carcinoma prognosis
por: Niknami, Zohreh, et al.
Publicado: (2020)

BTBD7 Downregulates E-Cadherin and Promotes Epithelial-Mesenchymal Transition in Lung Cancer
por: Shu, Jie, et al.
Publicado: (2019)

E-cadherin to P-cadherin switching in lobular breast cancer with tubular elements
por: Christgen, Matthias, et al.
Publicado: (2020)

Breast carcinoma cells re-express E-cadherin during mesenchymal to epithelial reverting transition
por: Chao, Yvonne L, et al.
Publicado: (2010)

A Positive Role of Cadherin in Wnt/β-Catenin Signalling during Epithelial-Mesenchymal Transition
por: Howard, Sara, et al.
Publicado: (2011)

Cadherin-6B is proteolytically processed during epithelial-to-mesenchymal transitions of the cranial neural crest
por: Schiffmacher, Andrew T., et al.
Publicado: (2014)

Recycling of E-Cadherin: A Potential Mechanism for Regulating Cadherin Dynamics
por: Le, Tam Luan, et al.
Publicado: (1999)

Progression of Oral Squamous Cell Carcinoma Accompanied with Reduced E-Cadherin Expression but Not Cadherin Switch
por: Hashimoto, Takashi, et al.
Publicado: (2012)

Chlamydia trachomatis Infection Is Associated with E-Cadherin Promoter Methylation, Downregulation of E-Cadherin Expression, and Increased Expression of Fibronectin and α-SMA—Implications for Epithelial-Mesenchymal Transition
por: Rajić, Jovana, et al.
Publicado: (2017)

E-cadherin loss alters cytoskeletal organization and adhesion in non-malignant breast cells but is insufficient to induce an epithelial-mesenchymal transition
por: Chen, Augustine, et al.
Publicado: (2014)

MiR-429 reverses epithelial-mesenchymal transition by restoring E-cadherin expression in bladder cancer
por: Wu, Chia-Lun, et al.
Publicado: (2016)

SIRT1 induces epithelial-mesenchymal transition by promoting autophagic degradation of E-cadherin in melanoma cells
por: Sun, Ting, et al.
Publicado: (2018)

Oncogenic effect of PHLDB2 is associated with epithelial–mesenchymal transition and E-cadherin regulation in colorectal cancer
por: Chen, Geng, et al.
Publicado: (2019)

Cadherin 13 Inhibits Pancreatic Cancer Progression and Epithelial-mesenchymal Transition by Wnt/β-Catenin Signaling
por: Xu, Dengfei, et al.
Publicado: (2020)

Neighborly relations: cadherins and mechanotransduction
por: Smutny, Michael, et al.
Publicado: (2010)

Sip1 mediates an E-cadherin-to-N-cadherin switch during cranial neural crest EMT
por: Rogers, Crystal D., et al.
Publicado: (2013)

EPB41L5 functions to post-transcriptionally regulate cadherin and integrin during epithelial–mesenchymal transition
por: Hirano, Mariko, et al.
Publicado: (2008)

Loss of E-cadherin expression is not a prerequisite for c-erbB2-induced epithelial-mesenchymal transition
por: NILSSON, GISELA M.A., et al.
Publicado: (2014)

Loss of E-cadherin and Acquisition of Vimentin in Epithelial-Mesenchymal Transition are Noble Indicators of Uterine Cervix Cancer Progression
por: Myong, Na-Hye
Publicado: (2012)

Small molecule/ML327 mediated transcriptional de-repression of E-cadherin and inhibition of epithelial-to-mesenchymal transition
por: An, Hanbing, et al.
Publicado: (2015)

Cadherin-6B proteolysis promotes the neural crest cell epithelial-to-mesenchymal transition through transcriptional regulation
por: Schiffmacher, Andrew T., et al.
Publicado: (2016)

PHF8 upregulation contributes to autophagic degradation of E-cadherin, epithelial-mesenchymal transition and metastasis in hepatocellular carcinoma
por: Zhou, Wuhua, et al.
Publicado: (2018)

Characteristics of bladder transitional cell carcinoma with E-cadherin and N-cadherin double-negative expression
por: LUO, YANG, et al.
Publicado: (2016)

The cadherin-binding specificities of B-cadherin and LCAM
Publicado: (1995)

Cadherin exits the junction by switching its adhesive bond
por: Hong, Soonjin, et al.
Publicado: (2011)

E-cadherin transcriptional downregulation by promoter methylation but not mutation is related to epithelial-to-mesenchymal transition in breast cancer cell lines
por: Lombaerts, M, et al.
Publicado: (2006)

Jagged1-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug-induced repression of E-cadherin
por: Leong, Kevin G., et al.
Publicado: (2007)

E-cadherin re-expression shows in vivo evidence for mesenchymal to epithelial transition in clonal metastatic breast tumor cells
por: Palen, Katie, et al.
Publicado: (2016)

Correction to: PHF8 upregulation contributes to autophagic degradation of E-cadherin, epithelial-mesenchymal transition and metastasis in hepatocellular carcinoma
por: Zhou, Wuhua, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_emjn043ndc3jgot5j78uctpg4r