Engineering a surrogate human heteromeric α/β glycine receptor orthosteric site exploiting the structural homology and stability of acetylcholine-binding protein

Protein-engineering methods have been exploited to produce a surrogate system for the extracellular neurotransmitter-binding site of a heteromeric human ligand-gated ion channel, the glycine receptor. This approach circumvents two major issues: the inherent experimental difficulties in working with...

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Detalles Bibliográficos
Autores principales: Dawson, Alice, Trumper, Paul, de Souza, Juliana Oliveira, Parker, Holly, Jones, Mathew J., Hales, Tim G., Hunter, William N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2019
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6830221/
https://www.ncbi.nlm.nih.gov/pubmed/31709057
http://dx.doi.org/10.1107/S205225251901114X

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6830221/
https://www.ncbi.nlm.nih.gov/pubmed/31709057
http://dx.doi.org/10.1107/S205225251901114X

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