Optimisation of novel 4, 8-disubstituted dihydropyrimido[5,4-b][1,4]oxazine derivatives as potent GPR 119 agonists

GPR119 is a promising target for discovery of anti-type 2 diabetes mellitus agents. We described the optimisation of a novel series of pyrimido[5,4-b][1,4]oxazine derivatives as GPR119 agonists. Most designed compounds exhibited good agonistic activities. Among them, compound 10 and 15 demonstrated...

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Detalles Bibliográficos
Autores principales: Fang, Yuanying, Zhang, Shaokun, Li, Min, Xiong, Lijuan, Tu, Liangxing, Xie, Saisai, Jin, Yi, Liu, Yanhua, Yang, Zunhua, Liu, Ronghua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6830257/
https://www.ncbi.nlm.nih.gov/pubmed/31656107
http://dx.doi.org/10.1080/14756366.2019.1681988

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6830257/
https://www.ncbi.nlm.nih.gov/pubmed/31656107
http://dx.doi.org/10.1080/14756366.2019.1681988

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