Phosphonamidates are the first phosphorus-based zinc binding motif to show inhibition of β-class carbonic anhydrases from bacteria, fungi, and protozoa

A primary strategy to combat antimicrobial resistance is the identification of novel therapeutic targets and anti-infectives with alternative mechanisms of action. The inhibition of the metalloenzymes carbonic anhydrases (CAs, EC 4.2.1.1) from pathogens (bacteria, fungi, and protozoa) was shown to p...

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Detalles Bibliográficos
Autores principales: Alissa, Siham A., Alghulikah, Hanan A., Alothman, Zeid A., Osman, Sameh M., Del Prete, Sonia, Capasso, Clemente, Nocentini, Alessio, Supuran, Claudiu T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6830296/
https://www.ncbi.nlm.nih.gov/pubmed/31663383
http://dx.doi.org/10.1080/14756366.2019.1681987

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6830296/
https://www.ncbi.nlm.nih.gov/pubmed/31663383
http://dx.doi.org/10.1080/14756366.2019.1681987

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